Title Page

Objective

 General Introduction

Genetic Markers

Map Construction

QTL Mapping

References

Books

• Essential Cell Biology: An Introduction to the molecular biology of the cell (1998) Alberts, Bray, Johnson, Lewis, Raff, Roberts, Walter. Garland Publishing, Inc. New York & London. ISBN-0-8153-2045-0

• Modern Genetic Analysis (1999 - First Edition) Griffiths, Gelbart, Miller, Lewontin. W.H. Freeman and Company, New York. ISBN 0 7167 3118 5

• Human Molecular Genetics (1999 - Second Edition). Strachan & Read. Bios Scientific Publishers Limited. ISBN 1 85996 202 5

• Genetic data Analysis II (1996). Weir. Sinauer Associates, Inc. Publishers, Sunderland, Massachusetts. ISBN 0-87893-902-4

• Genetics and analysis of quantitative traits (1998). Michael Lynch & Bruce Walsh. Sinauer Associates, Inc. Sunderland, Massachusetts. ISBN 0-87893-481-2

• Introduction to Quantitative Genetics. 4th Edition (1996) Falconer, D.S. and T.F.C. Mackay. Longman Scientific and technical, New York.

Other

• Boehnke, M.; Lange, K.; Cox, D.R. (1991). Statistical methods for multipoint radiation hybrid mapping. Am. J. Hum. Genet. 49: 1174-1188.

• Botstein, D.; White, R.L.; Skolnick, M.; Davis, R.W. (1980). Construction of a genetic linkage map in the man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32: 314-331.

•  Bovenhuis, H.; Spelman, R.J. (2000). Selective genotyping to detect quantitative trait loci for multiple traits in outbred populations. J. Dairy Sci. 83: 173-180.

• Churchill, G.A.; Doerge, R.W.(1995). Empirical threshold values for quantitative trait mapping. Genetics 138: 963-971.

• Coppieters, W.; Kvasz, A.; Arranz, J.J.; Grisart, B.; Farnir, F.; Mackinnon, M. & Georges, M. (1998). A rank-based non parametric method to map QTL in outbred half-sib pedigrees: application to milk production in a grand-daughter design. Genetics 149:1547-1555.

• Darvasi, A.; Soller, M. (1992). Selective genotyping for determination of linkage between a marker locus and a quantitative trait locus. Theor. Appl. Genet. 85: 353-359.

• Farnir, F.; Coppieters, W.; Arranz, J.-J.; Berzi, P.; Cambisano, N.; Grisart, B.; Karim, L.; Marcq, F.; Moreau, L.; Mni, M.; Nezer, C.; Simon, P.; Vanmanshoven, P.; Wagenaar, D.; Georges, M. (2000). Extensive genome-wide linkage disequilibrium in cattle. Genome Research 10: 220-227.

• Farnir, F.; Grisart, B.; Coppieters, W.; Riquet, J.; Berzi, P.; Cambisano, N.; Karim, L.; Mni, M.; Simon, P.; Wagenaar, D.; Georges, M. (2000). Simultaneous mining of linkage and linkage disequilibrium to fine-map QTL in outbred half-sib designs. In preparation

• Georges, M.; Nielsen, D.; Mackinnon, M.; Mishra, A.; Okimoto, R.; Pasquino, A.T.; Sargeant, L.S.; Sorensen, A.; Steele, M.R.; Zhao, X.; Womack, J.E.; Hoeschele, I. (1995) Mapping quantitative trait loci controlling milk production by exploiting progeny testing. Genetics 139: 907-920.

• Knott S., Elsen J. M., Haley C. (1996). Methods for multiple-marker mapping of quantitative trait loci in half-sib populations. Theor. Appl. Genet. 93: 71-80.

• Kruglyak, L.; Lander, E.S. (1995). A nonparametric approach for mapping QTL. Genetics 139: 1421-1428.

• Kruglyak, L.; Lander, E.S. (1995). Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am. J. Hum. Genet. 57: 439-454.

• Lander, E.S.; Botstein, D. (1989). Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199.

• Lander E.S.; Kruglyak, L. (1995). Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 11: 241-247.

• Lange, K.; Boehnke, M.; Cox, D.R.; Lunetta, K.L. (1995). Statistical methods for polyploid radiation hybrid mapping. Genome Research 5: 136-150.

• Lipkin, E.; Mosig, M.O.; Darvasi, A.; Ezra, E.; Shalom, A.; Friedmann, A.; Soller, M. (1998). Quantitative trait locus mapping in dairy cattle by means of selective milk DNA pooling using dinucleotide microsatellite markers: analysis of milk protein percentage. Genetics 149: 1557-1567.

• Lunetta, K.L.; Boehnke, M. (1994). Multipoint radiation hybrid mapping: comparison of methods, sample size requirements, and optimal study characteristics. Genomics 21: 92-103.

• Riquet, J.; Coppieters, W.; Cambisano, N.; Arranz, J.-J.; Berzi, P.; Davis, S.; Grisart, B.; Farnir, F.; Karim, L.; Mni, M.; Simon, P.; Taylor, J.; Vanmanshoven, P.; Wagenaar, D.; Womack, J.E.; Georges, M. (1999). Identity-by-descent fine-mapping of QTL in outbred populations: application to milk production in dairy cattle. Proceedings of the National Academy of Sciences, USA 96: 9252-9257.

• Soller, M.; Brody, T.; Genizi, A. (1976). On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. Theor. Appl. Genet. 47: 35-39.

• Spelman, R.L.; Coppieters, W.; Karim, L.; Van Arendonk, J.A.M.; Bovenhuis, H. (1996) Quantitative trait loci analysis for five milk production traits on chromosome six in the dutch Holstein-Friesian population. Genetics 144:1799-1808.

• Spielman R., McGinnis R., Ewens W. (1993). Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52: 506-516.

• Terwilliger, J.D. (1995). A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymoprhis marker loci. Am. J. Hum. Genet. 56: 777-787.

• VanRaden, P.M.; Wiggans, G.R. (1991). Derivation, calculation, and use of National Animal Model Information. J. Dairy Sci. 74: 2737-2746.

• Visscher, P.M.; Thompson, R.; Haley, C.S. (1996). Confidence intervals in QTL mapping by bootstrapping. Genetics 143: 1013-1020.

• Weller JI, Kashi Y, Soller M (1990) Power of daughter and granddaughter designs for determining linkage between marker loci and quantitative trait loci in dairy cattle. J. Dairy Sci. 73:2525-2537.