Title Page

Objective

 General Introduction

Genetic Markers

Map Construction

QTL Mapping in Outbred Half-Sib Pedigrees

 Introduction
The Grand-Daughter Design
Single Marker Mapping versus Multimarker or Interval Mapping
Interval Mapping of QTL in Outbred Half-Sib Pedigrees Using Maximum Likelihood
Interval Mapping of QTL in Outbred Half-Sib Pedigrees Using Linear Regression
Interval Mapping of QTL in Outbred Half-Sib Pedigrees Using a Rank-Based Non Parametric Test
Determining Appropriate Significance Thresholds
Estimating a Confidence Interval for the QTL Location by Bootstrapping
Potential Overestimation of the QTL Effect
Selective Genotyping
DNA Pooling
Using Linkage Disequilibrium to Fine-Map QTL

References