Title Page

Objective

 General Introduction

Genetic Markers

Definition

 Genetic markers are the basic tool of the geneticist

 Three properties define a genetic marker:

• locus-specific
• polymorphic in the studied population
• easily genotyped

 The quality of a genetic marker is typically measured by its:

• Heterozygosity in the population of interest.
• PIC (Botstein et al., 1980):
  • = Polymorphism Information Content
  • = The probability that one could identify which homologue of a given parent was transmitted to a given offspring, the other parent being genotyped as well.
  • = probability that the parent is heterozygous x probability that the offspring is informative

Phenotypic Markers
 Blood Groups
 Biochemical Polymorphisms
 RFLPs
 Minisatellites or VNTR Markers
 Microsatellites or SSR Markers
 SNPs

 Map Construction

QTL Mapping in Outbred Half-Sib Pedigrees

References